Methyl Vanillate → Methyl 4-hydroxy-3-iodo-5-methoxybenzoate

HRID 423259노트

반응식

HRID 423259 반응식
[CH3:1][O:2][C:3](=[O:13])[C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[C:6]([O:11][CH3:12])[CH:5]=1.[I:14]N1C(=O)CCC1=O>O1CCCC1>[CH3:1][O:2][C:3](=[O:13])[C:4]1[CH:5]=[C:6]([O:11][CH3:12])[C:7]([OH:10])=[C:8]([I:14])[CH:9]=1

참가 물질

4

반응물 2

HCID 19844Methyl VanillateHCID 120273N-Iodosuccinimide

생성물 1

HCID 53426739Methyl 4-hydroxy-3-iodo-5-methoxybenzoate수율 113.6%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 4-hydroxy-3-methoxybenzoic acid methyl ester (5.0 g) in tetrahydrofuran (20 mL) was added N-iodosuccinimide (6.17 g) at 0° C., and the mixture was stirred for 1 hour. The precipitated solid was filtered, washed with water, and dried to give the title compound (9.60 g).

후처리

  1. filtrationThe precipitated solid was filtered
  2. washwashed with water
  3. customdried

출처 및 근거

ORD 기록
ord-91f5d4f170584cc5abefa9ba12bcba63
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08101774B2

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