Hydrochloric Acid → 6-[6-((r)-3-Amino-pyrrolidin-1-yl)-pyridin-3-yl]-2-(4-chloro-phenyl)-6h-thieno[2,3-c]pyridin-7-one, hydrochloride

HRID 423428노트

반응식

HRID 423428 반응식
[NH2:1][C@@H:2]1[CH2:6][CH2:5][N:4]([C:7]2[N:12]=[CH:11][C:10]([N:13]3[CH:18]=[CH:17][C:16]4[CH:19]=[C:20]([C:22]5[CH:27]=[CH:26][C:25]([Cl:28])=[CH:24][CH:23]=5)[S:21][C:15]=4[C:14]3=[O:29])=[CH:9][CH:8]=2)[CH2:3]1.C(Cl)Cl.Cl>CO.CCO>[ClH:28].[NH2:1][C@@H:2]1[CH2:6][CH2:5][N:4]([C:7]2[N:12]=[CH:11][C:10]([N:13]3[CH:18]=[CH:17][C:16]4[CH:19]=[C:20]([C:22]5[CH:27]=[CH:26][C:25]([Cl:28])=[CH:24][CH:23]=5)[S:21][C:15]=4[C:14]3=[O:29])=[CH:9][CH:8]=2)[CH2:3]1

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 6344DichloromethaneHCID 247581026-[6-((R)-3-amino-pyrrolidin-1-yl)-pyridin-3-yl]-2-(4-chloro-phenyl)-6H-thieno[2,3-c]pyridin-7-one

생성물 1

HCID 247581016-[6-((r)-3-Amino-pyrrolidin-1-yl)-pyridin-3-yl]-2-(4-chloro-phenyl)-6h-thieno[2,3-c]pyridin-7-one, hydrochloride수율 93%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 887Methanol용매

실험 절차

Prepare the HCl salt by dissolving the free base in MeOH and CH2Cl2 then adding 1N HCl in EtOH and evaporating. Suspend the salt in Et2O and filter to give 0.386 g (93%) of the title compound. MS/ES m/z (35Cl) 423.0 [M+H]+.

후처리

  1. customevaporating
  2. filtrationfilter

출처 및 근거

ORD 기록
ord-aabb87edc62f46e181d8303ea79d0fcb
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08101764B2

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