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Triphenylphosphine → 1,1-Dimethylethyl 4-({[4-(5-bromo-2-pyridinyl)phenyl]oxy}methyl)-1-piperidinecarboxylate

HRID 423523
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HRID 423523 반응식
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([OH:14])=[CH:10][CH:9]=2)=[N:6][CH:7]=1.[C:15]([N:22]1[CH2:27][CH2:26][CH:25]([CH2:28]O)[CH2:24][CH2:23]1)([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16].C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.N(C(OC(C)C)=O)=NC(OC(C)C)=O>C1COCC1>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([O:14][CH2:28][CH:25]3[CH2:26][CH2:27][N:22]([C:15]([O:17][C:18]([CH3:19])([CH3:21])[CH3:20])=[O:16])[CH2:23][CH2:24]3)=[CH:10][CH:9]=2)=[N:6][CH:7]=1
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HCID 11776TriphenylphosphineHCID 75555Diisopropyl diazene-1,2-dicarboxylateHCID 2764081Tert-butyl 4-(hydroxymethyl)piperidine-1-carboxylateHCID 1363884624-(5-Bromo-2-pyridinyl)phenol

생성물 1

HCID 666732311,1-Dimethylethyl 4-({[4-(5-bromo-2-pyridinyl)phenyl]oxy}methyl)-1-piperidinecarboxylate수율 60.4%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

1,1-Dimethylethyl 4-({[4-(5-bromo-2-pyridinyl)phenyl]oxy}methyl)-1-piperidinecarboxylate (0.27 g, 60%) was prepared as a white solid from 4-(5-bromo-2-pyridinyl)phenol (0.25 g, 1.0 mmol), N-Boc-4-piperidinemethanol (0.23 g, 1.0 mmol) and Ph3P (0.27 g, 1.0 mmol) in THF (7 mL) followed by diisopropyl azodicarboxylate (0.22 g, 94%, 1.0 mmol) in THF (3 mL) in a manner similar to Example 1, Step 2. 1H NMR (400 MHz, CDCl3): δ 8.69 (s, 1H), 7.92 (d, 2H, J=8.8 Hz), 7.85 (d, 1H, J=8.5 Hz), 7.57 (d, 1H, J=8.5 Hz), 6.97 (d, 2H, J=8.8 Hz), 4.25-4.10 (m, 2H), 3.86 (d, 2H, J=6.4 Hz), 2.85-2.70 (m, 2H), 2.05-1.90 (m, 1H), 1.90-1.80 (m, 2H), 1.46 (s, 9H), 1.35-1.20 (m, 2H); LRMS (ESI), m/z 446/448 (M+H).

출처 및 근거

ORD 기록
ord-186e50a3000d4f189c36790753d34f78
출처 데이터셋
uspto-grants-2012_01
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08101634B2

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