Hydrochloric Acid → 1-(Trifluoromethyl)cyclopropanamine hydrochloride

반응식

[F:1][C:2]([F:15])([F:14])[C:3]1([NH:6]C(=O)OC(C)(C)C)[CH2:5][CH2:4]1.[ClH:16]>>[ClH:16].[F:1][C:2]([F:15])([F:14])[C:3]1([NH2:6])[CH2:5][CH2:4]1

참가 물질

반응물 2

HCID 313Hydrochloric Acid

HCID 11658639Tert-butyl [1-(trifluoromethyl)cyclopropyl]carbamate

생성물 1

HCID 116511961-(Trifluoromethyl)cyclopropanamine hydrochloride수율 91%

실험 절차

Tert-butyl 1-(trifluoromethyl)cyclopropylcarbamate (4.08 g, 18.3 mmol) was suspended in 1 N HCl(aq) (150 mL) and stirred at reflux for 3.5 h. The solution was concentrated in vacuo and the residue was triturated with acetone. The filtrate was collected, concentrated, and the residue triturated with diethyl ether to afford 2.67 g (91%) of 1-(trifluoromethyl)cyclopropylamine hydrochloride as a white solid.

후처리

temperatureat reflux for 3.5 h
concentrationThe solution was concentrated in vacuo
customthe residue was triturated with acetone
customThe filtrate was collected
concentrationconcentrated
customthe residue triturated with diethyl ether

출처 및 근거

ORD 기록: ord-156c063e1b044551b05abc469f8230ec
출처 데이터셋: uspto-grants-2013_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08536187B2

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