Tetrahydrofuran → [4-Bromo-2-(methanesulfonyl)phenyl]methanol
반응식
[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[C:4]([S:10]([CH3:13])(=[O:12])=[O:11])[CH:3]=1.C1COCC1.[BH4-].[Na+]>CCO>[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][OH:7])=[C:4]([S:10]([CH3:13])(=[O:12])=[O:11])[CH:3]=1참가 물질
5
실험 절차
To a solution of 4-bromo-2-methansulfonyl-benzaldehyde (1.0 g, 3.88 mmol) in EtOH (11 mL)/THF (2.5 mL) was added NaBH4 (1.29 g, 34.2 mmol) in three portions. The reaction was carefully quenched with water and the product was extracted with EtOAc, dried (Na2SO4), and purified by silica gel chromatography to give 735 mg of (4-bromo-2-methansulfonyl-phenyl)-methanol.
후처리
- customThe reaction was carefully quenched with water
- extractionthe product was extracted with EtOAc
- dry with materialdried (Na2SO4)
- custompurified by silica gel chromatography
출처 및 근거
- ORD 기록
- ord-3d88b6e748454650a9020d7c708611a7
- 출처 데이터셋
- uspto-grants-2013_09
- 특허 번호
- US08536187B2
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