1,2-Dichloroethane → 2-[(6-Bromohexanoyl)oxy]propyl acrylate

HRID 424304

반응식

HRID 424304 반응식
[Br:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7]([OH:9])=[O:8].[C:10]([O:14][CH2:15][CH:16](O)[CH3:17])(=[O:13])[CH:11]=[CH2:12].C(Cl)CCl>C(Cl)Cl>[C:10]([O:14][CH2:15][CH:16]([O:8][C:7](=[O:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][Br:1])[CH3:17])(=[O:13])[CH:11]=[CH2:12]

참가 물질

5

반응물 3

HCID 111,2-DichloroethaneHCID 202106-Bromohexanoic acidHCID 612492-Hydroxypropyl acrylate

생성물 1

HCID 590050292-[(6-Bromohexanoyl)oxy]propyl acrylate

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

반응 조건

온도
0 °C

실험 절차

To a 0° C. cooled mixture of 6-bromohexanoic acid (9.89 g), 2-hydroxypropyl acrylate (6 g), in CH2Cl2 (30 ml), EDC (7.89 g) was added. After being stirred for 30 min the reaction mixture was diluted with additional 20 ml of CH2Cl2 and stirring was continued for 16 h at room temperature. It was then filtered over celite and the filtrate was evaporated to dryness. The obtained beige-yellow residue was purified by silica column chromatography to give nearly pure material as transparent oil.

후처리

  1. stirringstirring
  2. waitwas continued for 16 h at room temperature
  3. filtrationIt was then filtered over celite
  4. customthe filtrate was evaporated to dryness
  5. customThe obtained beige-yellow residue was purified by silica column chromatography
  6. customto give nearly pure material as transparent oil

출처 및 근거

ORD 기록
ord-0e5407f232de4411a3a215497f6e7f7d
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08105662B2

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