1,2-Dichloroethane → (2S)-2-methylbutyl 2,5-bis[(4-{[6-(acryloyloxy)hexyl]oxy}benzoyl)oxy]benzoate

HRID 424308

반응식

HRID 424308 반응식
[C:1]([O:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][O:12][C:13]1[CH:21]=[CH:20][C:16]([C:17]([OH:19])=[O:18])=[CH:15][CH:14]=1)(=[O:4])[CH:2]=[CH2:3].O[C:23]1[CH:36]=[CH:35][C:34]([OH:37])=[CH:33][C:24]=1[C:25]([O:27][CH2:28][C@@H:29]([CH3:32])[CH2:30][CH3:31])=[O:26].[CH2:38](Cl)[CH2:39]Cl>CN(C1C=CN=CC=1)C.C(Cl)Cl>[C:1]([O:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][O:12][C:13]1[CH:14]=[CH:15][C:16]([C:17]([O:19][C:23]2[CH:36]=[CH:35][C:34]([O:37][C:17](=[O:18])[C:16]3[CH:15]=[CH:14][C:13]([O:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][O:5][C:1](=[O:4])[CH:38]=[CH2:39])=[CH:21][CH:20]=3)=[CH:33][C:24]=2[C:25]([O:27][CH2:28][C@@H:29]([CH3:32])[CH2:30][CH3:31])=[O:26])=[O:18])=[CH:20][CH:21]=1)(=[O:4])[CH:2]=[CH2:3]

참가 물질

6

반응물 3

HCID 111,2-DichloroethaneHCID 37135654-((6-(Acryloyloxy)hexyl)oxy)benzoic acidHCID 59005024(2S)-2-methylbutyl 2,5-dihydroxybenzoate

생성물 1

HCID 59005014(2S)-2-methylbutyl 2,5-bis[(4-{[6-(acryloyloxy)hexyl]oxy}benzoyl)oxy]benzoate

시약·촉매·용매 2

HCID 142844-(Dimethylamino)pyridine촉매HCID 6344Dichloromethane용매

실험 절차

A mixture consisting of 4-{[6-(acryloyloxy)hexyl]oxy}benzoic acid (2.92 g), (2S)-2-methylbutyl 2,5-dihydroxybenzoate (1.1 g), DMAP (0.24 g) and EDC (2 g) in CH2Cl2 (30 ml) was stirred for 6 h at room temperature. The yellowish reaction mixture was then evaporated to dryness and the obtained pasty residue was purified by column chromatography over silica to give nearly pure material as transparent oil which becomes pasty upon standing for about 24 h.

후처리

  1. customThe yellowish reaction mixture
  2. customwas then evaporated to dryness
  3. customthe obtained pasty residue was purified by column chromatography over silica
  4. customto give nearly pure material as transparent oil which
  5. waitupon standing for about 24 h.

출처 및 근거

ORD 기록
ord-14bc3a45110c4d50afb991f214510206
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08105662B2

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