Sodium Hydroxide → (2S)-2-(4-bromophenyl)oxirane
반응식
[OH-].[Na+].Br[CH2:4][C@H:5]([C:7]1[CH:12]=[CH:11][C:10]([Br:13])=[CH:9][CH:8]=1)[OH:6]>C(OCC)C>[Br:13][C:10]1[CH:11]=[CH:12][C:7]([C@H:5]2[CH2:4][O:6]2)=[CH:8][CH:9]=1참가 물질
4
실험 절차
Aqueous sodium hydroxide (1M, 400 ml) was added to 2-bromo-(1S)-1-(4-bromophenyl)ethanol (77.0 g) in diethyl ether (400 ml) and stirred at room temperature for 5 hours. The organic layer was separated and water layer was extracted with ether. Combined organic layer was washed with brine and dried over anhydrous sodium sulfate. Removal of the solvent yielded (2S)-2-(4-bromophenyl)oxirane (55.0 g) as a pale brown oil.
후처리
- customThe organic layer was separated
- extractionwater layer was extracted with ether
- washCombined organic layer was washed with brine
- dry with materialdried over anhydrous sodium sulfate
- customRemoval of the solvent
출처 및 근거
- ORD 기록
- ord-a2eb469c71b94d8f968070d6e48d7265
- 출처 데이터셋
- uspto-grants-2012_01
- 특허 번호
- US08106045B2
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