2-(Methylamino)ethanol → HCID 57786876, 화합물

HRID 424621

반응식

HRID 424621 반응식
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([CH3:9])[C:6]([S:10](Cl)(=[O:12])=[O:11])=[C:5]([CH3:14])[C:4]=1[CH3:15].[CH3:16][NH:17][CH2:18][CH2:19][OH:20].CCN(CC)CC>C1COCC1>[OH:20][CH2:19][CH2:18][N:17]([CH3:16])[S:10]([C:6]1[C:7]([CH3:9])=[CH:8][C:3]([O:2][CH3:1])=[C:4]([CH3:15])[C:5]=1[CH3:14])(=[O:12])=[O:11]

참가 물질

5

반응물 3

HCID 80162-(Methylamino)ethanolHCID 8471TriethylamineHCID 5627874-Methoxy-2,3,6-trimethylbenzenesulfonyl chloride

생성물 1

HCID 57786876HCID 57786876, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

A soln. of 4-methoxy-2,3,6-trimethylbenzenesulfonyl chloride (2.29 g, 9.19 mmol) in THF (30 ml) was added dropwise to a soln. of 2-methylaminoethanol (0.89 g, 0.95 ml, 11.8 mmol) and Et3N (5 ml) in THF (15 ml) at 0° C. The mixture was subsequently stirred at RT for 5 h and then concentrated i. vac., the residue was taken up in NaHCO3 soln. and the mixture was extracted with EtOAc (3×30 ml). The combined organic phases were dried with Na2SO4 and concentrated i. vac.

후처리

  1. customat 0° C
  2. concentrationconcentrated i
  3. extractionand the mixture was extracted with EtOAc (3×30 ml)
  4. dry with materialThe combined organic phases were dried with Na2SO4
  5. concentrationconcentrated i

출처 및 근거

ORD 기록
ord-5eb047e36058445ebe869cd0fd5a19a9
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08106055B2

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