Water → HCID 86611704, 화합물
반응식
[OH2:1].Br[CH2:3][C:4]1[C:12]2[C:7](=[N:8][C:9]([Cl:13])=[CH:10][CH:11]=2)[S:6][N:5]=1>CS(C)=O>[Cl:13][C:9]1[N:8]=[C:7]2[S:6][N:5]=[C:4]([CH2:3][OH:1])[C:12]2=[CH:11][CH:10]=1참가 물질
4
반응 조건
- 온도
- 80 °C
실험 절차
Water (8 mL) was added to a solution of 3-(bromomethyl)-6-chloroisothiazolo[5,4-b]pyridine (19.0 mmol) in dimethylsulfoxide (40 mL) and the reaction mixture was heated at 80° C. for 1.5 h. The reaction mixture was then quenched with water (50 mL) and the resulting solution was extracted with ethyl acetate (3×40 mL). The combined organic layers were dried (magnesium sulfate) and concentrated to provide the crude (6-chloroisothiazolo[5,4-b]pyridin-3-yl) methanol as a yellow solid.
후처리
- customThe reaction mixture was then quenched with water (50 mL)
- extractionthe resulting solution was extracted with ethyl acetate (3×40 mL)
- dry with materialThe combined organic layers were dried (magnesium sulfate)
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-c8ace23114ed45648083a50a0e6f3842
- 출처 데이터셋
- uspto-grants-2012_01
- 특허 번호
- US08106066B2
반응 노트
불러오는 중…