Benzyl Bromide → 2-(Benzylthio)pyrimidine-4,6-diol

HRID 424657

반응식

HRID 424657 반응식
[OH-].[Na+].[SH:3][C:4]1[N:9]=[C:8]([OH:10])[CH:7]=[C:6]([OH:11])[N:5]=1.[CH2:12](Br)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>C(O)C.O>[CH2:12]([S:3][C:4]1[N:9]=[C:8]([OH:10])[CH:7]=[C:6]([OH:11])[N:5]=1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

참가 물질

5

반응물 3

HCID 7498Benzyl BromideHCID 14798Sodium HydroxideHCID 178516656HCID 178516656, 화합물

생성물 1

HCID 1785166522-(Benzylthio)pyrimidine-4,6-diol

시약·촉매·용매 1

HCID 19096565Water ethanol용매

반응 조건

온도
60 °C

실험 절차

A solution of sodium hydroxide (3.30 g) in ethanol/H2O (60 ml/60 ml) was added to 2-mercaptopyrimidine-4,6-diol (10.00 g) and the mixture stirred for 10 min. Benzyl bromide (13.45 g) was then added dropwise and the mixture heated at 60° C. for 2 h. The reaction was cooled to 0° C. for 1 h before the precipitate was filtered and washed with H2O (100 ml) and then dried in vacuo to afford the subtitle compound as a cream solid. Yield: 15.0 g.

후처리

  1. temperatureThe reaction was cooled to 0° C. for 1 h before the precipitate
  2. filtrationwas filtered
  3. washwashed with H2O (100 ml)
  4. customdried in vacuo

출처 및 근거

ORD 기록
ord-342092aec2cf48a0a856821b20271eb9
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08106063B2

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