Hydrochloric Acid → (4,6-Dimethylpyrimidin-2-yl)cyanamide

HRID 4247

반응식

HRID 4247 반응식
[C:1]([NH:3][C:4]([NH2:6])=[NH:5])#[N:2].[CH3:7][C:8](=O)[CH2:9][C:10](=O)[CH3:11].Cl>O>[C:1]([NH:3][C:4]1[N:6]=[C:10]([CH3:11])[CH:9]=[C:8]([CH3:7])[N:5]=1)#[N:2]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 31261AcetylacetoneHCID 178418324HCID 178418324, 화합물

생성물 1

HCID 521618(4,6-Dimethylpyrimidin-2-yl)cyanamide수율 70%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
120 °C

실험 절차

A mixture of 42 g (0.5 mol) of cyanoguanidine ("dicyanodiamide") and 50 g (0.5 mol) of 2,4-pentanedione ("acetylacetone") is heated to 120° C. for 15 hours. The reaction mixture is then cooled, after which 500 ml of water are added and the solution is acidified with hydrochloric acid at 0° C. to 10° C. The product obtained in crystalline form during this procedure is isolated by filtering it off under suction. 51.8 g (70% of theory) of 2-cyanoamino-4,6-dimethyl-pyrimidine of melting point 205° C. are obtained.

후처리

  1. temperatureThe reaction mixture is then cooled
  2. customThe product obtained in crystalline form during this procedure
  3. customis isolated
  4. filtrationby filtering it off under suction

출처 및 근거

ORD 기록
ord-337e60123b3b4db0a8dbe09ecff88ae9
출처 데이터셋
uspto-grants-1988_02
특허 번호
US04725303

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