Methyl 3,3,3-trifluoro-2-oxopropanoate → 3-cyclopropyl-alpha-hydroxy-2,5-dihydro-5-oxo-1-phenyl-alpha-trifluoromethyl-1H-pyrazole-4-acetic acid methyl ester

HRID 424909

반응식

HRID 424909 반응식
[CH:1]1([C:4]2[NH:5][N:6]([C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=3)[C:7](=[O:9])[CH:8]=2)[CH2:3][CH2:2]1.[F:16][C:17]([F:25])([F:24])[C:18](=[O:23])[C:19]([O:21][CH3:22])=[O:20]>C(Cl)(Cl)Cl>[CH3:22][O:21][C:19](=[O:20])[C:18]([OH:23])([C:17]([F:25])([F:24])[F:16])[C:8]1[C:7](=[O:9])[N:6]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[NH:5][C:4]=1[CH:1]1[CH2:3][CH2:2]1

참가 물질

4

반응물 2

HCID 2734931Methyl 3,3,3-trifluoro-2-oxopropanoateHCID 660226995-cyclopropyl-2-phenyl-1H-pyrazol-3-one

생성물 1

HCID 667016013-cyclopropyl-alpha-hydroxy-2,5-dihydro-5-oxo-1-phenyl-alpha-trifluoromethyl-1H-pyrazole-4-acetic acid methyl ester

시약·촉매·용매 1

HCID 6212Chloroform용매

반응 조건

온도
80 °C

실험 절차

To a chloroform solution (5 ml) of 3-cyclopropyl-1-phenyl-5-pyrazolone (100 mg, 0.5 mmol), methyl trifluoropyruvate (78 mg, 0.5 mmol) was added at room temperature and the mixture was stirred at 80° C. for 2 hours. After removing the solvent under reduced pressure, the title compound was obtained as a colorless solid (178 mg).

후처리

  1. customAfter removing the solvent under reduced pressure

출처 및 근거

ORD 기록
ord-bc90968e13994b3ba137de9c5efb7ee7
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08106086B2

연결된 노트

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