Methyl 3,3,3-trifluoro-2-oxopropanoate → 2,5-dihydro-alpha-hydroxy-1-(3-methoxyphenyl)-3-methyl-5-oxo-alpha-trifluoromethyl-1H-pyrazole-4-acetic acid methyl ester

HRID 424917

반응식

HRID 424917 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([N:9]2[C:13](=[O:14])[CH:12]=[C:11]([CH3:15])[NH:10]2)[CH:6]=[CH:7][CH:8]=1.[F:16][C:17]([F:25])([F:24])[C:18](=[O:23])[C:19]([O:21][CH3:22])=[O:20]>C(Cl)(Cl)Cl>[CH3:22][O:21][C:19](=[O:20])[C:18]([OH:23])([C:17]([F:25])([F:24])[F:16])[C:12]1[C:13](=[O:14])[N:9]([C:5]2[CH:6]=[CH:7][CH:8]=[C:3]([O:2][CH3:1])[CH:4]=2)[NH:10][C:11]=1[CH3:15]

참가 물질

4

반응물 2

HCID 2734931Methyl 3,3,3-trifluoro-2-oxopropanoateHCID 544140731-(3-Methoxyphenyl)-3-methyl-5-pyrazolone

생성물 1

HCID 441398202,5-dihydro-alpha-hydroxy-1-(3-methoxyphenyl)-3-methyl-5-oxo-alpha-trifluoromethyl-1H-pyrazole-4-acetic acid methyl ester

시약·촉매·용매 1

HCID 6212Chloroform용매

반응 조건

온도
80 °C

실험 절차

To a chloroform solution (5 ml) of 1-(3-methoxyphenyl)-3-methyl-5-pyrazolone (102 mg, 0.5 mmol), methyl trifluoropyruvate (78 mg, 0.5 mmol) was added at room temperature and the mixture was stirred at 80° C. for 2 hours. After removing the solvent under reduced pressure, the title compound was obtained as a pale yellow solid (180 mg).

후처리

  1. customAfter removing the solvent under reduced pressure

출처 및 근거

ORD 기록
ord-402bb15c00e54e0f9a407b31bc28e1f8
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08106086B2

연결된 노트

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