2,2,2-Trifluoroethanol → 2-(2,2,2-Trifluoroethoxy)ethan-1-ol

반응식

[F:1][C:2]([F:6])([F:5])[CH2:3][OH:4].[O:7]1[CH2:11][CH2:10]OC1=O>CCN(CC)CC>[F:1][C:2]([F:6])([F:5])[CH2:3][O:4][CH2:10][CH2:11][OH:7]

참가 물질

반응 조건

온도: 100 °C

실험 절차

2,2,2-trifluoroethanol (15 g), 1,3-dioxolan-2-one (19.8 g) and Et3N (15 g) were mixed together, and then the mixture was heated to 100° C. and stirred for 24 h. Then the reaction mixture was distilled to obtain intermediate BR (12.7 g).

후처리

distillationThen the reaction mixture was distilled
customto obtain intermediate BR (12.7 g)

출처 및 근거

ORD 기록: ord-30655cb2a7d84943813024b34a828b71
출처 데이터셋: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08106021B2

반응 노트

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참가 물질

반응물 2

HCID 64092,2,2-Trifluoroethanol

HCID 7303Ethylene carbonate

생성물 1

HCID 2558542-(2,2,2-Trifluoroethoxy)ethan-1-ol

시약·촉매·용매 1

HCID 8471Triethylamine용매

반응 조건

온도: 100 °C

실험 절차

후처리

distillationThen the reaction mixture was distilled
customto obtain intermediate BR (12.7 g)

출처 및 근거

ORD 기록: ord-30655cb2a7d84943813024b34a828b71
출처 데이터셋: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08106021B2

반응 노트

불러오는 중…