Hydrochloric Acid → Methyl 2-acetamido-3-(4-bromophenyl)propanoate

HRID 425394노트

반응식

HRID 425394 반응식
Cl.[C:2]([NH:5][CH:6]([CH2:10][C:11]1[CH:16]=[CH:15][C:14]([Br:17])=[CH:13][CH:12]=1)[C:7]([OH:9])=[O:8])(=[O:4])[CH3:3].[CH3:18]O>>[C:2]([NH:5][CH:6]([CH2:10][C:11]1[CH:16]=[CH:15][C:14]([Br:17])=[CH:13][CH:12]=1)[C:7]([O:9][CH3:18])=[O:8])(=[O:4])[CH3:3]

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 5172487AC-P-Bromo-DL-phe-OH

생성물 1

HCID 21988848Methyl 2-acetamido-3-(4-bromophenyl)propanoate

실험 절차

Hydrogen chloride (4 M in 1,4-dioxane) (5 mL, 20 mmol) was added to an ambient temperature solution of 2-(acetylamino)-3-(4-bromophenyl)propanoic acid (10 g, 34.9 mmol) in methanol (50 mL). After stirring at ambient temperature overnight, the reaction mixture was concentrated in vacuo to afford methyl 2-(acetylamino)-3-(4-bromophenyl)propanoate which was used in the subsequent step without further purification.

후처리

  1. concentrationthe reaction mixture was concentrated in vacuo

출처 및 근거

ORD 기록
ord-989949343d964697890efaa31f5e1070
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08106070B2

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