Water → Methyl 1-benzylpiperidine-4-carboxylate

HRID 42561

반응식

HRID 42561 반응식
[NH:1]1[CH2:6][CH2:5][CH:4]([C:7]([O:9][CH3:10])=[O:8])[CH2:3][CH2:2]1.C(N(CC)CC)C.[CH2:18](Br)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.O>C(Cl)(Cl)Cl>[CH2:18]([N:1]1[CH2:6][CH2:5][CH:4]([C:7]([O:9][CH3:10])=[O:8])[CH2:3][CH2:2]1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

참가 물질

6

반응물 4

HCID 962Water2회HCID 7498Benzyl BromideHCID 8471TriethylamineHCID 424914Methyl isonipecotate

생성물 1

HCID 11436222Methyl 1-benzylpiperidine-4-carboxylate수율 924.2%

시약·촉매·용매 1

HCID 6212Chloroform용매2회

실험 절차

To a solution of methyl piperidine-4-carboxylate (10.00 g, 6.4 mmol) and triethylamine (10.32 g, 10.2 mmol) in CHCl3 (100 mL), benzyl bromide (14.69 g, 8.6 mmol) was added under argon atmosphere while cooling with a water and ice bath. The mixture was stirred at room temperature overnight. CHCl3 and water were added and the two phases were separated. The aqueous phase was extracted with CHCl3. The organic phase was dried over Na2SO4 and concentrated to dryness, to afford 13.80 g of the desired compound as an orange solid (yield: 88%).

후처리

  1. customthe two phases were separated
  2. extractionThe aqueous phase was extracted with CHCl3
  3. dry with materialThe organic phase was dried over Na2SO4
  4. concentrationconcentrated to dryness

출처 및 근거

ORD 기록
ord-613a553cbe3646d580f88062a12ccac2
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08536194B2

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