Sodium Hydroxide → 2-Methyl-benzoxazole-4-carboxylic acid-(1S,2S,5R)-[7-methyl-3-(2-methyl-5-m-tolyl-thiazole-4-carbonyl)-3-aza-bicyclo[3.3.0]oct-2-ylmethyl]-amide

HRID 425837

반응식

HRID 425837 반응식
[NH2:1][CH2:2][C@H:3]1[N:10]([C:11]([C:13]2[N:14]=[C:15]([CH3:25])[S:16][C:17]=2[C:18]2[CH:19]=[C:20]([CH3:24])[CH:21]=[CH:22][CH:23]=2)=[O:12])[CH2:9][C@H:8]2[C@@H:4]1[CH2:5][CH:6]([CH3:26])[CH2:7]2.[CH3:27][C:28]1[O:29][C:30]2[C:31](=[C:33]([C:37](O)=[O:38])[CH:34]=[CH:35][CH:36]=2)[N:32]=1.[OH-].[Na+]>O.CO>[CH3:26][CH:6]1[CH2:5][C@H:4]2[C@H:8]([CH2:9][N:10]([C:11]([C:13]3[N:14]=[C:15]([CH3:25])[S:16][C:17]=3[C:18]3[CH:19]=[C:20]([CH3:24])[CH:21]=[CH:22][CH:23]=3)=[O:12])[C@@H:3]2[CH2:2][NH:1][C:37]([C:33]2[CH:34]=[CH:35][CH:36]=[C:30]3[O:29][C:28]([CH3:27])=[N:32][C:31]=23)=[O:38])[CH2:7]1

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 183546282-Methyl-1,3-benzoxazole-4-carboxylic acidHCID 59411601[(1S,2S,5R)-2-aminomethyl-7-methyl-3-aza-bicyclo[3.3.0]oct-3-yl]-(2-methyl-5-m-tolyl-thiazol-4-yl)-methanone

생성물 1

HCID 251543012-Methyl-benzoxazole-4-carboxylic acid-(1S,2S,5R)-[7-methyl-3-(2-methyl-5-m-tolyl-thiazole-4-carbonyl)-3-aza-bicyclo[3.3.0]oct-2-ylmethyl]-amide

시약·촉매·용매 1

HCID 22242641Methanol--water (1/1)용매

실험 절차

prepared by reaction of [(1S,2S,5R)-2-aminomethyl-7-methyl-3-aza-bicyclo[3.3.0]oct-3-yl]-(2-methyl-5-m-tolyl-thiazol-4-yl)-methanone with 2-methyl-benzoxazole-4-carboxylic acid which was synthesised by saponification of the corresponding methyl ester derivative (Goldstein S et al. J. of Heterocyclic. Chem. 1990, 27, 2, 335-336) with NaOH in a mixture water/MeOH.

출처 및 근거

ORD 기록
ord-6f10c240cfab416b98f7714c9ee4cdb6
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08106215B2

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