Pyridine → HCID 66703605, 화합물

HRID 425985

반응식

HRID 425985 반응식
[F:1][C:2]1[CH:10]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:8]=[CH:7][C:3]=1[C:4](Cl)=[O:5].N1C=CC=CC=1.[NH2:21][C:22]1[CH:31]=[C:30]2[C:25]([CH2:26][CH2:27][C:28](=[O:33])[N:29]2[CH3:32])=[CH:24][CH:23]=1>O>[F:1][C:2]1[CH:10]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:8]=[CH:7][C:3]=1[C:4]([NH:21][C:22]1[CH:31]=[C:30]2[C:25]([CH2:26][CH2:27][C:28](=[O:33])[N:29]2[CH3:32])=[CH:24][CH:23]=1)=[O:5]

참가 물질

5

반응물 3

HCID 1049PyridineHCID 1455802-Fluoro-4-(trifluoromethyl)benzoyl chlorideHCID 336993947-amino-1-methyl-3,4-dihydroquinolin-2(1H)-one

생성물 1

HCID 66703605HCID 66703605, 화합물

시약·촉매·용매 1

HCID 962Water용매

실험 절차

2-Fluoro-4-(trifluoromethyl)benzoyl chloride was added to a pyridine solution of 7-amino-1-methyl-3,4-dihydroquinolin-2(1H)-one, followed by stirring at room temperature for 12 hours. Water was added to the reaction liquid, followed by stirring for 30 minutes and then the precipitated crystals were collected by filtration to obtain 2-fluoro-N-(1-methyl-2-oxo-1,2,3,4-tetrahydroquinolin-7-yl)-4-(trifluoromethyl)benzamide.

후처리

  1. stirringby stirring for 30 minutes
  2. filtrationthe precipitated crystals were collected by filtration

출처 및 근거

ORD 기록
ord-37e90418f05547b9ae14e3e6437759f8
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08106190B2

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