2-(Ethylthio)ethanol → Ethylmercaptoethyl 2-[4-(4-chlorophenoxy-methyl)-phenoxy]-propionate

HRID 426441

반응식

HRID 426441 반응식
[Cl:1][C:2]1[CH:22]=[CH:21][C:5]([O:6][CH2:7][C:8]2[CH:20]=[CH:19][C:11]([O:12][CH:13]([CH3:18])[C:14]([O:16][CH3:17])=[O:15])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[CH2:23]([S:25][CH2:26]CO)[CH3:24]>[Na]>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:6][CH2:7][C:8]2[CH:20]=[CH:19][C:11]([O:12][CH:13]([CH3:18])[C:14]([O:16][CH2:17][CH2:26][S:25][CH2:23][CH3:24])=[O:15])=[CH:10][CH:9]=2)=[CH:21][CH:22]=1

참가 물질

4

반응물 2

HCID 80752-(Ethylthio)ethanolHCID 19834514Methyl 2-[4-(4-Chlorophenoxy-methyl)-phenoxy]-propionate

생성물 1

HCID 54273417Ethylmercaptoethyl 2-[4-(4-chlorophenoxy-methyl)-phenoxy]-propionate수율 76.1%

시약·촉매·용매 1

HCID 5360545Sodium촉매

반응 조건

온도
100 °C

실험 절차

A mixture consisting of 6.4 gm of methyl 2-[4-(4-chlorophenoxy-methyl)-phenoxy]-propionate and 2.12 gm of 2-ethylmercapto-ethanol was heated to 100° C. on an oil bath, 0.02 gm of sodium was added to the hot mixture, and it was then heated at 150° C. for five hours, the pressure being periodically reduced to 150 mm Hg. Thereafter, the reaction product was isolated as an oil, yielding 6.0 gm (76% of theory) of the ester named in the heading.

후처리

  1. temperaturewas then heated at 150° C. for five hours
  2. customThereafter, the reaction product was isolated as an oil

출처 및 근거

ORD 기록
ord-87befb2a9f384fe995a3e7b3f08bd736
출처 데이터셋
uspto-grants-1979_10
특허 번호
US04169720

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