Cysteamine Hydrochloride → HCID 20213304, 화합물

HRID 426472노트

반응식

HRID 426472 반응식
Cl.[NH2:2][CH2:3][CH2:4][SH:5].CC(C)([O-])C.[K+].C(O[CH2:16][C:17]1[O:18][C:19]([CH2:22][CH2:23][CH2:24][CH2:25][N:26]([CH3:28])[CH3:27])=[CH:20][CH:21]=1)(=O)C>CN(C)C=O.CO>[CH3:28][N:26]([CH3:27])[CH2:25][CH2:24][CH2:23][CH2:22][C:19]1[O:18][C:17]([CH2:16][S:5][CH2:4][CH2:3][NH2:2])=[CH:21][CH:20]=1

참가 물질

6

반응물 3

HCID 9082Cysteamine HydrochlorideHCID 23452115[5-[4-(Dimethylamino)butyl]-2-furanyl]methyl ethanoateHCID 23665647Potassium tert-butoxide

생성물 1

HCID 20213304HCID 20213304, 화합물

시약·촉매·용매 2

HCID 887Methanol용매HCID 6228Dimethylformamide용매

실험 절차

Cysteamine hydrochloride (4.5 g) was added to a cooled solution of potassium-t-butoxide (8.98 g) in dry dimethylformamide (125 ml). The mixture was stirred for 20 min and [5-[4-(dimethylamino)butyl]-2-furanyl]methyl ethanoate (9.6 g) was added. The reaction was heated at 90° for 4 hr, poured onto an ice-water mixture and extracted with chloroform. Distillation of the organic extract gave a yellow oil which after column chromatography on silica, using methanol/0.880 ammonia (9:1) as eluent, and a further distillation afforded a colourless oil b.p. 140°/0.05 mm Hg. Found: C, 60.81; H, 9.86; N, 10.44, Calc. for C13H24N2OS: C, 60.91; H, 9.44; N, 10.93%.

후처리

  1. temperatureThe reaction was heated at 90° for 4 hr
  2. extractionextracted with chloroform
  3. distillationDistillation of the
  4. extractionorganic extract
  5. customgave a yellow oil which after column chromatography on silica
  6. distillationa further distillation

출처 및 근거

ORD 기록
ord-fd293ff6400543f1b1b37217aad4e657
출처 데이터셋
uspto-grants-1979_10
특허 번호
US04169855

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