Cyclohexylamine → N-Cyclohexylacetoacetamide

HRID 426542

반응식

HRID 426542 반응식
[CH:1]1([NH2:7])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH2:8]=[C:9]1[O:13][C:11](=[O:12])[CH2:10]1>C1C=CC=CC=1>[CH:1]1([NH:7][C:11](=[O:12])[CH2:10][C:9](=[O:13])[CH3:8])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

4

반응물 2

HCID 7965CyclohexylamineHCID 12661Diketene

생성물 1

HCID 70805N-Cyclohexylacetoacetamide

시약·촉매·용매 1

HCID 241Benzene용매

반응 조건

온도
20 °C

실험 절차

A mixture of 500 ml of benzene and 99 g of cyclohexyl amine were introduced over 30 minutes to 84 g of diketene and after stirring for 4 hours at 20° C., the mixture was evaporated to dryness by distillation under reduced pressure. The residue was taken up in isopropyl ether and the solution was cooled and vacuum filtered. The recovered precipitate was dried and crystallized from isopropyl ether to obtain 137 g of N-cyclohexyl-acetylacetamide melting at 74° C.

후처리

  1. customthe mixture was evaporated to dryness by distillation under reduced pressure
  2. temperaturethe solution was cooled
  3. filtrationvacuum filtered
  4. customThe recovered precipitate was dried
  5. customcrystallized from isopropyl ether

출처 및 근거

ORD 기록
ord-1badeddcfd504b04a8ef06cf61e0a4a7
출처 데이터셋
uspto-grants-1979_10
특허 번호
US04170465

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