Hydrochloric Acid → 3-(2H-tetrazol-5-yl)-2-(trifluoromethyl)pyridine
반응식
[F:1][C:2]([F:12])([F:11])[C:3]1[N:10]=[CH:9][CH:8]=[CH:7][C:4]=1[C:5]#[N:6].[N-:13]=[N+:14]=[N-:15].[Na+].[Cl-].[NH4+].Cl>CN(C)C=O>[N:6]1[NH:13][N:14]=[N:15][C:5]=1[C:4]1[C:3]([C:2]([F:11])([F:1])[F:12])=[N:10][CH:9]=[CH:8][CH:7]=1참가 물질
6
반응 조건
- 온도
- 85 °C
실험 절차
A mixture of 2-(trifluoromethyl)nicotinonitrile (0.43 g, 2.50 mmol), sodium azide (0.24 g, 3.75 mmol), and ammonium chloride (0.20 g, 3.75 mmol) in dimethylformamide (2.5 mL) was stirred at 85° C. for 20 hours. After cooling to room temperature, the reaction mixture was poured onto water (20 mL) and acidified with dilute hydrochloric acid. The resulting precipitate was collected, washed with water and dried to yield 3-(2H-tetrazol-5-yl)-2-(trifluoromethyl)pyridine, 0.484 g (90%).
후처리
- temperatureAfter cooling to room temperature
- additionthe reaction mixture was poured onto water (20 mL)
- customThe resulting precipitate was collected
- washwashed with water
- customdried
출처 및 근거
- ORD 기록
- ord-e37ea56ca5574a2bafaf368875ccb062
- 출처 데이터셋
- uspto-grants-2013_09
- 특허 번호
- US08536203B2
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