Diazomethane → HCID 85913004, 화합물

HRID 426780노트

반응식

HRID 426780 반응식
[C:1]([O:4][CH:5]1[C:9](=[O:10])[C:8]([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][C:17]([OH:19])=[O:18])=[CH:7][CH2:6]1)(=[O:3])[CH3:2].[N+](=[CH2:22])=[N-]>C(OCC)C>[C:1]([O:4][CH:5]1[C:9](=[O:10])[C:8]([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][C:17]([O:19][CH3:22])=[O:18])=[CH:7][CH2:6]1)(=[O:3])[CH3:2]

참가 물질

4

반응물 2

HCID 9550DiazomethaneHCID 203899457-[4-(Acetyloxy)-5-oxocyclopent-1-en-1-yl]heptanoic acid

생성물 1

HCID 85913004HCID 85913004, 화합물수율 100.7%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

실험 절차

A solution of (±)-7-[4-acetoxy-5-oxo-cyclopent-1-enyl]heptanoic acid (1.0 g; prepared as described in Example 1) in dry diethyl ether (10 ml) was treated with a solution of diazomethane (0.32 g) in dry diethyl ether (5 ml). The reaction mixture was allowed to stand at ambient temperature for 2.5 hours. The diethyl ether and excess diazomethane were removed in vacuo to yield methyl (±)-7-[4-acetoxy-5-oxocyclopent-1-enyl]heptanoate (1.06 g). [νmax 1740 cm-1, 1720 cm-1, 1625 cm-1, 1380 cm-1, 1240 cm-1 ; λmax (ethanol) 232 mμ; N.M.R. (approximately 10% solution in deuterochloroform); multiplets at 7.28δ, 3.35-2.7δ, 2.7-2.2δ, 2.5-2.0δ, 2.0-1.05δ, doublet of doublets at 5.15δ (J=3 cycles/second and 7 cycles/second), singlets at 3.7δ and 2.1δ.] .

후처리

  1. customThe diethyl ether and excess diazomethane were removed in vacuo

출처 및 근거

ORD 기록
ord-a0edea824111470d831650896b1d2c5d
출처 데이터셋
uspto-grants-1979_10
특허 번호
US04171375

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