(2-Bromophenyl)boronic acid → 5-(2-Bromophenyl)-1,3-benzodioxole-4-carbaldehyde

반응식

Br[C:2]1[CH:10]=[CH:9][C:5]2[O:6][CH2:7][O:8][C:4]=2[C:3]=1[CH:11]=[O:12].[Br:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1B(O)O>>[Br:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[C:2]1[CH:10]=[CH:9][C:5]2[O:6][CH2:7][O:8][C:4]=2[C:3]=1[CH:11]=[O:12]

참가 물질

반응물 2

HCID 2773294(2-Bromophenyl)boronic acid

HCID 110316405-Bromo-1,3-benzodioxole-4-carboxaldehyde

생성물 1

HCID 866586805-(2-Bromophenyl)-1,3-benzodioxole-4-carbaldehyde

실험 절차

The process described in Method B was followed. 5-Bromo-1,3-benzodioxole-4-carbaldehyde (1.15 g, 5.00 mmol) and 2-bromophenylboronic acid (1.10 g, 5.50 mmol) were used to obtain the title compound. The crude product was purified by column chromatography with a mixture of hexane:ethyl acetate (9:1) as the eluent.

출처 및 근거

ORD 기록: ord-89304411dabb487c91269d35b72d6f0f
출처 데이터셋: uspto-grants-2013_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08536210B2

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