Hydrochloric Acid → 1-[2-(2-Naphthyl)-2-(methoxy)ethyl]imidazole hydrochloride

HRID 426949노트

반응식

HRID 426949 반응식
[ClH:1].[CH:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][C:3]=1[CH:12]([O:19][CH3:20])[CH2:13][N:14]1[CH:18]=[CH:17][N:16]=[CH:15]1>>[ClH:1].[CH:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][C:3]=1[CH:12]([O:19][CH3:20])[CH2:13][N:14]1[CH:18]=[CH:17][N:16]=[CH:15]1

참가 물질

3

반응물 2

HCID 313Hydrochloric AcidHCID 12698958HCID 12698958, 화합물

생성물 1

HCID 126989591-[2-(2-Naphthyl)-2-(methoxy)ethyl]imidazole hydrochloride

실험 절차

Ethereal hydrogen chloride is added dropwise to a stirred solution of 1.0 g. of 1-[2-(2-naphthyl)-2-(methoxy)ethyl]imidazole in 100 ml. of anhydrous ether until precipitation is complete. The product is filtered off, washed with ether, air dried and recrystallized from ethyl acetate/methanol to yield 1-[2-(2-naphthyl)-2-(methoxy)ethyl]imidazole hydrochloride, m.p. 171.5°-172.5° C.

후처리

  1. customof anhydrous ether until precipitation
  2. filtrationThe product is filtered off
  3. washwashed with ether, air
  4. customdried
  5. customrecrystallized from ethyl acetate/methanol

출처 및 근거

ORD 기록
ord-9a4574fbc46e4c97bb3842766b4d06b0
출처 데이터셋
uspto-grants-1979_10
특허 번호
US04172141

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