2-Chloroveratraldehyde → 4-Chloro-1,3-benzodioxole-5-methanol

HRID 427284노트

반응식

HRID 427284 반응식
[Cl:1][C:2]1[C:9]([O:10]C)=[C:8]([O:12][CH3:13])[CH:7]=[CH:6][C:3]=1[CH:4]=[O:5].ClC1C2OCOC=2C=CC=1C=O.[BH4-].[Na+]>C1COCC1>[Cl:1][C:2]1[C:9]2[O:10][CH2:13][O:12][C:8]=2[CH:7]=[CH:6][C:3]=1[CH2:4][OH:5]

참가 물질

5

반응물 3

HCID 794452-ChloroveratraldehydeHCID 4311764Sodium borohydrideHCID 217955384-Chloro-1,3-benzodioxole-5-carboxaldehyde

생성물 1

HCID 217955394-Chloro-1,3-benzodioxole-5-methanol

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

2-Chloro-3,4-dimethoxybenzaldehyde was converted to 4-chloro-1,3-benzodioxole-5-carboxaldehyde by the method of S. T. Ross, R. G. Franz, J. W. Wilson, R. A. Hahn and H. M. Sarau, J. Heterocyclic Chemistry, (1986) 23, 1805. Reduction of the aldehyde was then carried out with sodium borohydride (1 equivalent) in THF at 0° C. to provide 4-chloro-1,3-benzodioxole-5-methanol (Examples 30A, 31 A).

출처 및 근거

ORD 기록
ord-f60acb3c539c43beb89640a4deff0810
출처 데이터셋
uspto-grants-2001_11
특허 번호
US06313100B1

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