Isobutylamine → Boc-Ile-NH-CH2-CH(CH3)2

HRID 427360

반응식

HRID 427360 반응식
[NH:1]([C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])[C@H:2]([C:7]([OH:9])=O)[C@H:3]([CH2:5][CH3:6])[CH3:4].[CH2:17]([NH2:21])[CH:18]([CH3:20])[CH3:19].C1C=CC2N(O)N=NC=2C=1.C1CCC(N=C=NC2CCCCC2)CC1>CN(C=O)C>[NH:1]([C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])[C@H:2]([C:7]([NH:21][CH2:17][CH:18]([CH3:20])[CH3:19])=[O:9])[C@H:3]([CH2:5][CH3:6])[CH3:4]

참가 물질

6

반응물 4

HCID 6558IsobutylamineHCID 10868DicyclohexylcarbodiimideHCID 757711-HydroxybenzotriazoleHCID 2724762tert-Butoxycarbonyl-L-isoleucine

생성물 1

HCID 131722955Boc-Ile-NH-CH2-CH(CH3)2

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

In a DMF solution containing 2.0 g of Boc-Ile-OH, 0.82 ml of isobutylamine, 1.27 g of HOBt and 2.06 g of DCC were added under ice cooling and the resultant mixture was stirred for 14 hr. The reaction mixture, after filtration, was treated similarly to that in Example 50 (Process 2), except for the crystallization solvent (hexane) to give 1.44 g of the title compound.

후처리

  1. additionwere added under ice cooling
  2. filtrationThe reaction mixture, after filtration
  3. additionwas treated similarly to that in Example 50 (Process 2)

출처 및 근거

ORD 기록
ord-f043d0260b1949569a14578a54763201
출처 데이터셋
uspto-grants-2001_11
특허 번호
US06313094B1

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