Nitrogen → 5-(4-Nitro-[1,2,3]triazol-2-ylmethyl)-furan-2-carbaldehyde

HRID 42740

반응식

HRID 42740 반응식
N#N.[N+:3]([C:6]1[CH:10]=[N:9][N:8]([CH2:11][C:12]2[O:16][C:15]([CH2:17][OH:18])=[CH:14][CH:13]=2)[N:7]=1)([O-:5])=[O:4]>C(C#N)(C)=O.O=[Mn]=O>[N+:3]([C:6]1[CH:10]=[N:9][N:8]([CH2:11][C:12]2[O:16][C:15]([CH:17]=[O:18])=[CH:14][CH:13]=2)[N:7]=1)([O-:5])=[O:4]

참가 물질

5

반응물 2

HCID 947NitrogenHCID 67365277(5-((4-nitro-2H-1,2,3-triazol-2-yl)methyl)furan-2-yl)methanol

생성물 1

HCID 866494765-(4-Nitro-[1,2,3]triazol-2-ylmethyl)-furan-2-carbaldehyde

시약·촉매·용매 2

HCID 14801Manganese dioxide촉매HCID 694302-Oxopropiononitrile용매

실험 절차

In a flame dried round-bottomed flask equipped with a magnetic stir bar and under inert atmosphere (N2), a solution of [5-(4-nitro-[1,2,3]triazol-2-ylmethyl)-furan-2-yl]-methanol (248 mg, 1.11 mmol) in AcCN (11.0 mL) was treated at rt with MnO2 (644 mg, 6.67 mmol). The reaction mixture was stirred at rt overnight before being filtered through Celite and the solvent was removed under reduced pressure. Purification of the residue by FC (40:60 hept-EA) gave the title compound: TLC:rf (40:60 hept-EA)=0.26. LC-MS-conditions 02: tR=0.84 min.

후처리

  1. filtrationbefore being filtered through Celite
  2. customthe solvent was removed under reduced pressure
  3. customPurification of the residue by FC (40:60 hept-EA)

출처 및 근거

ORD 기록
ord-3dcb4a5ff9174205af0466bbdc927706
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08536209B2

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