4'-Fluoroacetophenone → 1-(4-Acetylphenyl)-4-(4-pyridyl)piperazine

HRID 427456

반응식

HRID 427456 반응식
[C:1]([C:11]1[CH:16]=[CH:15][C:14]([N:17]2[CH2:22][CH2:21][N:20]([C:23]3[CH:28]=[CH:27][N:26]=[CH:25][CH:24]=3)[CH2:19][CH2:18]2)=[CH:13][CH:12]=1)(=[O:10])[CH:2]=CC1C=CC=CC=1.CC(C1C=CC(F)=CC=1)=O.FC1C=CC(C(C2C=CC=CC=2)=O)=CC=1>>[C:1]([C:11]1[CH:12]=[CH:13][C:14]([N:17]2[CH2:18][CH2:19][N:20]([C:23]3[CH:28]=[CH:27][N:26]=[CH:25][CH:24]=3)[CH2:21][CH2:22]2)=[CH:15][CH:16]=1)(=[O:10])[CH3:2]

참가 물질

4

반응물 3

HCID 98284'-FluoroacetophenoneHCID 676634-FluorobenzophenoneHCID 536791701-(4-Cinnamoylphenyl)-4-(4-pyridyl)piperazine

생성물 1

HCID 183571351-(4-Acetylphenyl)-4-(4-pyridyl)piperazine수율 40%

실험 절차

The 1-(4-acetylphenyl)-4-(4-pyridyl)piperazine used as starting material was prepared as in Example 32, using 4-fluoroacetophenone as starting material in place of 4-fluorobenzophenone to give 1-(4-acetylphenyl)-4-(4-pyridyl)piperazine (40% yield), m.p. 176-177° C.

후처리

  1. customwas prepared as in Example 32

출처 및 근거

ORD 기록
ord-56cc5e7890734fd8bc4174e1de91c4cf
출처 데이터셋
uspto-grants-2001_11
특허 번호
US06313127B1

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