Water → 2,3-Dimethyl-8-(2,6-dimethylbenzylamino)-imidazo[1,2-a]pyridine-6-carboxamide

HRID 427491

반응식

HRID 427491 반응식
S(O)(=O)(=O)C.[NH2:6][C:7]1[C:8]2[N:9]([C:16]([CH3:20])=[C:17]([CH3:19])[N:18]=2)[CH:10]=[C:11]([C:13]([NH2:15])=[O:14])[CH:12]=1.[CH2:21]([C:23]1[CH:30]=[CH:29][CH:28]=[C:27]([CH2:31]C)[C:24]=1[CH2:25]Cl)C.C(N(C(C)C)CC)(C)C.O>CN(C)C=O.C(Cl)Cl>[CH3:19][C:17]1[N:18]=[C:8]2[C:7]([NH:6][CH2:25][C:24]3[C:27]([CH3:31])=[CH:28][CH:29]=[CH:30][C:23]=3[CH3:21])=[CH:12][C:11]([C:13]([NH2:15])=[O:14])=[CH:10][N:9]2[C:16]=1[CH3:20]

참가 물질

7

반응물 4

HCID 962WaterHCID 81531DiisopropylethylamineHCID 183574358-Amino-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxamide mesylateHCID 183574492-(Chloromethyl)-1,3-diethylbenzene

생성물 1

HCID 97972452,3-Dimethyl-8-(2,6-dimethylbenzylamino)-imidazo[1,2-a]pyridine-6-carboxamide수율 53.3%

시약·촉매·용매 2

HCID 6228Dimethylformamide용매HCID 6344Dichloromethane용매

실험 절차

8-Amino-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxamide mesylate (4.0 g, 10.7 mmol), 2,6-diethylbenzylchloride (1.8 g, 9.9 mmol), diisopropylethylamin (3.0 g, 23.3 mmol) were stirred in dimethylformamide (20 ml) at 50° C. overnight and at 70° C. for 3 h. Water (60 ml) and methylene chloride were added and the organic layer was separated, dried and evaporated under reduced pressure. The residue was treated with diethyl ether and the product was filtred off to give 1.7 g (45%) of the title compound.

후처리

  1. customthe organic layer was separated
  2. customdried
  3. customevaporated under reduced pressure
  4. additionThe residue was treated with diethyl ether

출처 및 근거

ORD 기록
ord-80d10fb4fbbf4e17b0dd803562336d9d
출처 데이터셋
uspto-grants-2001_11
특허 번호
US06313137B1

연결된 노트

불러오는 중…