Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2,7-Dimethoxy-1-naphthaldehyde → 2-Hydroxy-7-methoxy-1-naphthaldehyde
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2,7-Dimethoxy-1-naphthaldehyde | HCID 293215 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 2-Hydroxy-7-methoxy-1-naphthaldehyde | HCID 10536097 | — |
반응 단계
After the dimethoxylated product obtained in Step B (2 g:9.25 mmol) has been dissolved in anhydrous dichloromethane, 97% BBr3Me2S complex (2.98 g:9.25 mmol:1 eq.) is introduced at ambient temperature. After 35 minutes of stirring, hydrolysis is carried out with a saturated solution of sodium hydrogen carbonate (pH=8). The product is extracted with dichloromethane and then purified on a silica column AcOEt/PE (3/7).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06313160B1 |
| 출처 데이터셋 | uspto-grants-2001_11 |
| ORD ID | ord-4b095e46f6eb4ea897f9a95701f82c92 |
| 출처 메모 | uspto-grants-2001_11 |