反应详情

After the dimethoxylated product obtained in Step B (2 g:9.25 mmol) has been dissolved in anhydrous dichloromethane, 97% BBr3Me2S complex (2.98 g:9.25 mmol:1 eq.) is introduced at ambient temperature. After 35 minutes of stirring, hydrolysis is carried out with a saturated solution of sodium hydrogen carbonate (pH=8). The product is extracted with dichloromethane and then purified on a silica column AcOEt/PE (3/7).

1. addition97% BBr3Me2S complex (2.98 g:9.25 mmol:1 eq.) is introduced at ambient temperature
2. customhydrolysis
3. extractionThe product is extracted with dichloromethane
4. custompurified on a silica column AcOEt/PE (3/7)