Hydrogen Peroxide → N,N-Diisopropyl-3-carbamoyl-3-phenylpropanamide

HRID 428341노트

반응식

HRID 428341 반응식
[CH:1]([N:4]([CH:17]([CH3:19])[CH3:18])[C:5](=[O:16])[CH2:6][CH:7]([C:14]#[N:15])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)([CH3:3])[CH3:2].[OH:20]O>CCO.[OH-].[Na+]>[CH:17]([N:4]([CH:1]([CH3:3])[CH3:2])[C:5](=[O:16])[CH2:6][CH:7]([C:14](=[O:20])[NH2:15])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)([CH3:19])[CH3:18]

참가 물질

5

반응물 2

HCID 784Hydrogen PeroxideHCID 18357355N,N-Diisopropyl-3-cyano-3-phenylpropanamide

생성물 1

HCID 18357397N,N-Diisopropyl-3-carbamoyl-3-phenylpropanamide

시약·촉매·용매 2

HCID 702Ethanol용매HCID 14798Sodium Hydroxide용매

실험 절차

N,N-Diisopropyl-3-cyano-3-phenylpropanamide (21.1 g, 82 mmol) was dissolved in EtOH (130 mL) and 2 M NaOH (100 mL). Hydrogen peroxide (30%, 20.2 mL, 200 mmol) was added and the mixture was stirred at ambient temperature for two hours. The resulting precipitate was filtered, washed with water and dried, yielding the title compound as white crystals, 15.6 g (69%): 1H NMR (CDCl3) δ1.09 (d, 3H), 1.19 (d, 3H), 1.31 (m, 6H), 2.51 (dd, 1H), 3.30 (dd, 1H), 3.41 (m, 1H), 4.02 (m, 1H), 4.18 (dd, 1H), 5.7 (br, 1H), 6.4 (br, 1H), 7.21-7.42 (m, 5H).

후처리

  1. filtrationThe resulting precipitate was filtered
  2. washwashed with water
  3. customdried

출처 및 근거

ORD 기록
ord-1056e1efe18f4c79ab3264c2884f9206
출처 데이터셋
uspto-grants-2001_11
특허 번호
US06313132B1

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