Acetone → 2,5-Difluoroanisole

HRID 428835노트

반응식

HRID 428835 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[OH:9].[CH3:10]C(C)=O.C(=O)([O-])[O-].[K+].[K+].S(OC)(OC)(=O)=O>O>[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[O:9][CH3:10]

참가 물질

6

반응물 4

HCID 180AcetoneHCID 6497Dimethyl SulfateHCID 11430Potassium CarbonateHCID 949522,5-Difluorophenol

생성물 1

HCID 27249892,5-Difluoroanisole

시약·촉매·용매 1

HCID 962Water용매

실험 절차

35.0 g of the product of Step A, 350 ml of acetone, 44.6 g of potassium carbonate and 40.7 g of dimethyl sulfate (neutralized on potassium bicarbonte) and was allowed to return to ambient temperature. Water was added and extraction was carried out with ether. The extracts were washed, dried and concentrated to dryness under reduced pressure to obtain 39.8 g of the desired product.

후처리

  1. customto return to ambient temperature
  2. extractionextraction
  3. washThe extracts were washed
  4. customdried
  5. concentrationconcentrated to dryness under reduced pressure

출처 및 근거

ORD 기록
ord-85bf43347afd4681b4f09c3276b2b80c
출처 데이터셋
uspto-grants-2001_11
특허 번호
US06313305B1

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