1,3-Dimethyl 2-(4-bromo-2-nitrophenyl)propanedioate → 4-Bromo-2-nitrophenylacetic Acid

HRID 429116

반응식

HRID 429116 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8](C(OC)=O)[C:9]([O:11]C)=[O:10])=[C:4]([N+:17]([O-:19])=[O:18])[CH:3]=1>Cl>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=[O:10])=[C:4]([N+:17]([O-:19])=[O:18])[CH:3]=1

참가 물질

3

반응물 1

HCID 157405961,3-Dimethyl 2-(4-bromo-2-nitrophenyl)propanedioate

생성물 1

HCID 2715514-Bromo-2-nitrophenylacetic Acid수율 89%

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

Crude dimethyl 4-bromo-2-nitrophenylmalonate was heated at 110° C. in 40 mL of 6N hydrochloric acid for 24 hours and then cooled. The precipitate was collected by filtration, washed with water and dried to give 5.3 g (89% yield) of 4-bromo-2-nitrophenylacetic acid as an off white solid.

후처리

  1. temperaturecooled
  2. filtrationThe precipitate was collected by filtration
  3. washwashed with water
  4. customdried

출처 및 근거

ORD 기록
ord-7465f6374dc54cc780d29ecbb9ef2218
출처 데이터셋
uspto-grants-2001_11
특허 번호
US06316429B1

연결된 노트

불러오는 중…