N-bromobutanimide → 1-Azido-4-(bromomethyl)benzene

HRID 429156

반응식

HRID 429156 반응식
[N:1]([C:4]1[CH:9]=[CH:8][C:7]([CH3:10])=[CH:6][CH:5]=1)=[N+:2]=[N-:3].[Br:11]N1C(=O)CCC1=O>C1C=CC=CC=1>[N:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][Br:11])=[CH:6][CH:5]=1)=[N+:2]=[N-:3]

참가 물질

4

반응물 2

HCID 67184N-bromobutanimideHCID 1374301-Azido-4-methylbenzene

생성물 1

HCID 118166671-Azido-4-(bromomethyl)benzene

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

To p-azidotoluene (2.2 mM) prepared as above was added N-bromosuccinimide (2.48 mM), and azo-isobutyronitrile (0.214 mM) in anhydrous benzene (5 ml). This was left to reflux for 5 hours, with the reaction being monitored by TLC. The organics were extracted into diethyl ether (3×15 ml), and water, dried over magnesium sulphate, and the excess solvent removed under vacuum. The p-azidobenzyl bromide formed was isolated using chromatographic techniques.

후처리

  1. waitThis was left
  2. temperatureto reflux for 5 hours, with the reaction
  3. extractionThe organics were extracted into diethyl ether (3×15 ml), and water
  4. dry with materialdried over magnesium sulphate
  5. customthe excess solvent removed under vacuum

출처 및 근거

ORD 기록
ord-bcba20d3fe4b41b1b42ec62cfc230ac1
출처 데이터셋
uspto-grants-2001_11
특허 번호
US06316455B1

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