2-Methylbenzyl alcohol → 2-Amino-3-(2-methylbenzyloxy)pyrazine
반응식
[CH3:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4][OH:5].[H-].[Na+].[NH2:12][C:13]1[C:18](Cl)=[N:17][CH:16]=[CH:15][N:14]=1>CN(C)C=O>[NH2:12][C:13]1[C:18]([O:5][CH2:4][C:3]2[CH:6]=[CH:7][CH:8]=[CH:9][C:2]=2[CH3:1])=[N:17][CH:16]=[CH:15][N:14]=1참가 물질
5
반응 조건
- 온도
- 65 °C
실험 절차
To a solution of 2-methylbenzyl alcohol (0.985 g) in N,N-dimethylformamide (10 ml) was added 62.8% sodium hydride (0.308 g) under a nitrogen atmosphere and then stirred for 30 minutes. 2-Amino-3-chloropyrazine (0.87 g) was added to the solution and the mixture was heated at 65° C. for 2 hours and poured onto crushed ice. The resulting precipitates were collected by filtration, washed with n-hexane, and dried in a desiccator to give 2-amino-3-(2-methylbenzyloxy)pyrazine (0.6 g).
후처리
- additionpoured
- customonto crushed ice
- customThe resulting precipitates
- filtrationwere collected by filtration
- washwashed with n-hexane
- customdried in a desiccator
출처 및 근거
- ORD 기록
- ord-163ac3e349334314939c73ed51b57929
- 출처 데이터셋
- uspto-grants-1988_02
- 특허 번호
- US04725601
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