Diiodomethane → HCID 18354426, 화합물

반응식

[CH3:1][S:2][C:3]1[N:8]=[C:7]([N:9]2[C:13]3[CH:14]=[CH:15][C:16](N)=[CH:17][C:12]=3[N:11]=[CH:10]2)[CH:6]=[CH:5][N:4]=1.C(ON=O)CC(C)C.[I:27]CI>>[CH3:1][S:2][C:3]1[N:8]=[C:7]([N:9]2[C:13]3[CH:14]=[CH:15][C:16]([I:27])=[CH:17][C:12]=3[N:11]=[CH:10]2)[CH:6]=[CH:5][N:4]=1

참가 물질

반응물 3

HCID 6346Diiodomethane

HCID 8053Isoamyl Nitrite

HCID 15549643HCID 15549643, 화합물

생성물 1

HCID 18354426HCID 18354426, 화합물

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온도: 100 °C

실험 절차

2-Methylthio-4-[5-aminobenzimidazol-1-yl]pyrimidine (EXAMPLE 3, 513 mg) was dissolved in diiodomethane (5 mL), isoamylnitrite (0.32 mL) was added and the resulting solution was heated to 100° C. for 30 minutes. Upon cooling to rt, the reaction mixture was directly purified by column chromatography (SiO2, 5% MeOH in CH2Cl2) to yield 342 mg of the title compound. Mass spectrum 371.1 (ESI) (M+).