Ammonia → 3-Methyl-4-bromo-5-aminobenzimidazole

HRID 429553

반응식

HRID 429553 반응식
[CH3:1][N:2]1[C:6]2[CH:7]=[C:8]([NH2:11])[CH:9]=[CH:10][C:5]=2[N:4]=[CH:3]1.[Br:12]Br.N>CC(O)=O>[CH3:1][N:2]1[C:6]2[C:7]([Br:12])=[C:8]([NH2:11])[CH:9]=[CH:10][C:5]=2[N:4]=[CH:3]1

참가 물질

5

반응물 3

HCID 222AmmoniaHCID 24408BromineHCID 136802831-Methyl-1H-benzimidazol-6-amine

생성물 1

HCID 129684523-Methyl-4-bromo-5-aminobenzimidazole수율 35%

시약·촉매·용매 1

HCID 176Acetic Acid용매

반응 조건

온도
25 °C

실험 절차

To a solution of 3-methyl-5-aminobenzimidazole (0.27 g, 1.8 mmol) in 10 ml of AcOH was added Br2 (0.10 ml). The reaction mixture was stirred for 1 h at 25° C. and concentrated in vacuo, yielding an oil which was subjected to column chromatography (NH3 sat'd 3% MeOH/CHCl3) to yield 0.14 g (0.62 mmol, 35%) of the desired product.

후처리

  1. concentrationconcentrated in vacuo
  2. customyielding an oil which

출처 및 근거

ORD 기록
ord-df82cdfd8d904547af74871b1b81e30c
출처 데이터셋
uspto-grants-2001_11
특허 번호
US06316637B1

연결된 노트

불러오는 중…