Dicyclohexylcarbodiimide → Retinamide

HRID 429588

반응식

HRID 429588 반응식
C1([N:7]=C=NC2CCCCC2)CCCCC1.[CH3:16][C:17]1[CH2:22][CH2:21][CH2:20][C:19]([CH3:24])([CH3:23])[C:18]=1/[CH:25]=[CH:26]/[C:27](/[CH3:37])=[CH:28]/[CH:29]=[CH:30]/[C:31](/[CH3:36])=[CH:32]/[C:33](O)=[O:34].ON1C2C=CC=CC=2N=N1>ClCCl>[CH3:16][C:17]1[CH2:22][CH2:21][CH2:20][C:19]([CH3:24])([CH3:23])[C:18]=1/[CH:25]=[CH:26]/[C:27](/[CH3:37])=[CH:28]/[CH:29]=[CH:30]/[C:31](/[CH3:36])=[CH:32]/[C:33]([NH2:7])=[O:34]

참가 물질

5

반응물 3

HCID 10868DicyclohexylcarbodiimideHCID 757711-HydroxybenzotriazoleHCID 444795Retinoic Acid

생성물 1

HCID 5370221Retinamide수율 62%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

3 g (0.0146 mole) of dicyclohexylcarbodiimide (DCC) was added to the solution of 4.48 g (0.0112 mole) of 1-amino-polyethylene glyco (molecular weight 400), 3.98 g (0.0133 mole) of retinoic acid and 1.51 g (0.0112 mole) of 1 -hydroxybenzotriazole in 40 ml of dry dichloromethane, and the reaction solution was then treated according to the same procedure as described in Example 1(A) to obtain the title compound (Yield 62%, Tm=−14° C., Rf=0.15).

후처리

  1. additionthe reaction solution was then treated

출처 및 근거

ORD 기록
ord-b24423e0eff84616a3d65f696c31a5ff
출처 데이터셋
uspto-grants-2001_11
특허 번호
US06316644B1

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