Chloroacetone → 8-(2-Methylbenzylamino)-2-methylimidazo[1,2-a]pyridine

HRID 4296

반응식

HRID 4296 반응식
[NH2:1][C:2]1[C:7]([NH:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[CH3:16])=[CH:6][CH:5]=[CH:4][N:3]=1.Cl[CH2:18][C:19](=O)[CH3:20]>C(O)C>[CH3:16][C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=1[CH2:9][NH:8][C:7]1[C:2]2[N:3]([CH:18]=[C:19]([CH3:20])[N:1]=2)[CH:4]=[CH:5][CH:6]=1

참가 물질

4

반응물 2

HCID 6571ChloroacetoneHCID 138258912-Amino-3-(2-methylbenzylamino)pyridine

생성물 1

HCID 201523218-(2-Methylbenzylamino)-2-methylimidazo[1,2-a]pyridine

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of 2-amino-3-(2-methylbenzylamino)pyridine (3.25 g) and chloroacetone (1.26 ml) in ethanol (65 ml) was refluxed for 18 hours and then evaporated in vacuo. To the residue was added aqueous sodium bicarbonate solution and the mixture was extracted with methylene chloride. The extract was washed with brine, dried over magnesium sulfate, and evaporated in vacuo. The oily residue was purified by column chromatography on silica gel (40 g) with a mixture of methylene chloride and ethyl acetate (10:1) as an eluent to give 8-(2-methylbenzylamino)-2-methylimidazo[1,2-a]pyridine (1.80 g).

후처리

  1. customevaporated in vacuo
  2. additionTo the residue was added aqueous sodium bicarbonate solution
  3. extractionthe mixture was extracted with methylene chloride
  4. washThe extract was washed with brine
  5. dry with materialdried over magnesium sulfate
  6. customevaporated in vacuo
  7. customThe oily residue was purified by column chromatography on silica gel (40 g) with a mixture of methylene chloride and ethyl acetate (10:1) as an eluent

출처 및 근거

ORD 기록
ord-022e022fa6a34c4ca3ba0dec5c804a5d
출처 데이터셋
uspto-grants-1988_02
특허 번호
US04725601

연결된 노트

불러오는 중…