Triethylamine → 2-Phenyl-4-(2-methylphenyl)cyclohexanone oxime

HRID 429719노트

반응식

HRID 429719 반응식
[C:1]1([CH:7]2[CH2:12][CH:11]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[CH3:19])[CH2:10][CH2:9][C:8]2=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(N(CC)CC)C.Cl.[NH2:29][OH:30]>CO.C(Cl)Cl>[C:1]1([CH:7]2[CH2:12][CH:11]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[CH3:19])[CH2:10][CH2:9][C:8]2=[N:29][OH:30])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 443297Hydroxyamine hydrochlorideHCID 18352673HCID 18352673, 화합물

생성물 1

HCID 867506802-Phenyl-4-(2-methylphenyl)cyclohexanone oxime수율 59%

시약·촉매·용매 1

HCID 21226129Dichloromethane methanol용매

실험 절차

2-Phenyl-4-(2-methylphenyl)cyclohexanone, 13.1 grams (49.5 mmol), was dissolved in 200 mL methanol/methylene chloride, followed by 11.1 mL (79.3 mmol) triethylamine and 5.5 grams (79.3 mmol) hydroxylamine hydrochloride. The solution was stirred at room temperature for 48 hours, the solvent evaporated, and the resulting solid washed with methanol and dried to afford 8.2 grams (59%) of a yellow solid.

후처리

  1. customthe solvent evaporated
  2. washthe resulting solid washed with methanol
  3. customdried

출처 및 근거

ORD 기록
ord-c21031604a664fc4a4ada417b0320005
출처 데이터셋
uspto-grants-2001_11
특허 번호
US06319915B1

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