Ammonia → N-(Phenylmethyl)thiourea

HRID 429798

반응식

HRID 429798 반응식
[CH2:1]([N:8]=[C:9]=[S:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH3:11].O>C1COCC1>[CH2:1]([NH:8][C:9]([NH2:11])=[S:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 222AmmoniaHCID 962WaterHCID 2346Benzyl Isothiocyanate

생성물 1

HCID 737375N-(Phenylmethyl)thiourea수율 108.1%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

96.3 g (366 mmoles) of benzylisothiocyanate were dissolved in 100 ml o THF and treated with 44.2 ml (732 mmoles) of 32% ammonia solution After 0.5 hour at 40-45° C., 300 ml of water were added and the THF removed in vacuo. The gummy suspension is treated with 200 ml of ether, the crystals collected and washed with water and ether. Suspension in 30 ml of methylenechloride and collection gave 65.77 g (64.2%) of benzyl-2-thiourea with mp 144-5° C.

후처리

  1. customthe THF removed in vacuo
  2. additionThe gummy suspension is treated with 200 ml of ether
  3. customthe crystals collected
  4. washwashed with water and ether
  5. customSuspension in 30 ml of methylenechloride and collection

출처 및 근거

ORD 기록
ord-ba70aae2e066437bb64b17f50dc28c49
출처 데이터셋
uspto-grants-2001_11
특허 번호
US06319928B1

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