Methyl iodide → 8-(2-Chlorobenzyloxy)-3-trimethylammoniomethyl-2-methylimidazo[1,2-a]pyridine iodide

HRID 4298

반응식

HRID 4298 반응식
[CH3:1][I:2].[Cl:3][C:4]1[CH:25]=[CH:24][CH:23]=[CH:22][C:5]=1[CH2:6][O:7][C:8]1[C:9]2[N:10]([C:14]([CH2:18][N:19]([CH3:21])[CH3:20])=[C:15]([CH3:17])[N:16]=2)[CH:11]=[CH:12][CH:13]=1>CC(C)=O>[I-:2].[Cl:3][C:4]1[CH:25]=[CH:24][CH:23]=[CH:22][C:5]=1[CH2:6][O:7][C:8]1[C:9]2[N:10]([C:14]([CH2:18][N+:19]([CH3:1])([CH3:21])[CH3:20])=[C:15]([CH3:17])[N:16]=2)[CH:11]=[CH:12][CH:13]=1

참가 물질

4

반응물 2

HCID 6328Methyl iodideHCID 138259368-(2-Chlorobenzyloxy)-3-dimethylaminomethyl-2-methylimidazo[1,2-a]pyridine

생성물 1

HCID 138259378-(2-Chlorobenzyloxy)-3-trimethylammoniomethyl-2-methylimidazo[1,2-a]pyridine iodide수율 101.7%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

Methyl iodide (3.48 g) was added dropwise to a solution of 8-(2-chlorobenzyloxy)-3-dimethylaminomethyl-2-methylimidazo[1,2-a]pyridine (7.8 g) in acetone (100 ml) at room temperature and the mixture was stirred for 24 hours. The resulting precipitate was collected by filtration, washed with acetone, and dried in a desiccator to give 8-(2-chlorobenzyloxy)-3-trimethylammoniomethyl-2-methylimidazo[1,2-a]pyridine iodide (11.35 g).

후처리

  1. filtrationThe resulting precipitate was collected by filtration
  2. washwashed with acetone
  3. customdried in a desiccator

출처 및 근거

ORD 기록
ord-91c2eee7c15b45b0a59d06a37df37e76
출처 데이터셋
uspto-grants-1988_02
특허 번호
US04725601

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