Phosgen toluene → HCID 86757603, 화합물

HRID 429828

반응식

HRID 429828 반응식
[C:1]([Cl:4])([Cl:3])=[O:2].C1(C)C=CC=CC=1.[CH3:12][O:13][C:14]1[CH:19]=[CH:18][C:17]([C:20]([CH2:23][CH2:24][NH:25][CH2:26][CH:27]2[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]2)([CH3:22])[CH3:21])=[CH:16][CH:15]=1>C(OCC)C>[ClH:3].[CH3:12][O:13][C:14]1[CH:15]=[CH:16][C:17]([C:20]([CH2:23][CH2:24][NH:25][CH2:26][CH:27]2[CH2:32][CH2:31][N:30]([C:1]([Cl:4])=[O:2])[CH2:29][CH2:28]2)([CH3:21])[CH3:22])=[CH:18][CH:19]=1

참가 물질

4

반응물 2

HCID 19083224Phosgen tolueneHCID 86757605HCID 86757605, 화합물

생성물 1

HCID 86757603HCID 86757603, 화합물수율 77.4%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

실험 절차

To a solution of 2 M phosgene/toluene (2.0 ml, 4 mmole) in ethyl ether (20 ml) was added a solution of N-[2-(4-methoxyphenyl-1-methylethyl]-N-ethyl-(piperidin-4-ylmethyl)amine (0.23 grams, 0.79 mmole) in ethyl ether (30 ml). After 30 minutes the precipitate was collected by filtration and dried in vacuo to give N-[2-(4-methoxyphenyl-1-methylethyl]-N-ethyl-(1-chlorocarbonylpiperidin-4-ylmethyl)amine hydrochloride (0.238 grams, 77%), m.p. 144-145° C.

후처리

  1. filtrationAfter 30 minutes the precipitate was collected by filtration
  2. customdried in vacuo

출처 및 근거

ORD 기록
ord-1ec6e23dc6ff4907bd35a8ee02bb9891
출처 데이터셋
uspto-grants-2001_11
특허 번호
US06319920B1

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