Water → HCID 3024740, 화합물
반응식
Cl[CH:2]([CH3:15])[C:3]([C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12](=[O:14])[CH3:13])=[CH:7][CH:6]=1)=[O:4].Cl.[CH3:17][NH:18][CH3:19].C([O-])([O-])=O.[K+].[K+].O>CC#N>[CH3:17][N:18]([CH3:19])[CH:2]([CH3:15])[C:3]([C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12](=[O:14])[CH3:13])=[CH:7][CH:6]=1)=[O:4]참가 물질
6
실험 절차
A mixture of N-[4-(2-chloro-1-oxopropyl)phenyl]acetamide (0.19 mol), N-methyl-methanamine hydrochloride (1:1)(0.38 mol) and K2CO3 (78.8 g) in CH3CN (1400 ml) was stirred and refluxed for 12 hours. The mixture was cooled, poured into water and extracted with CH2Cl2. The organic layer was dried, filtered and the solvent was evaporated, yielding 39.77 g (89%) of (±)-N-[4-[2-(dimethylamino)-1-oxopropyl]phenyl]-acetamide (interm. 9).
후처리
- temperaturerefluxed for 12 hours
- temperatureThe mixture was cooled
- extractionextracted with CH2Cl2
- customThe organic layer was dried
- filtrationfiltered
- customthe solvent was evaporated
출처 및 근거
- ORD 기록
- ord-04c3c912b628438dbdd996fdbfa111a5
- 출처 데이터셋
- uspto-grants-2001_11
- 특허 번호
- US06319939B1
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