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Sodium Hydroxide → HCID 69491289, 화합물

HRID 430605
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HRID 430605 반응식
C(O[BH-](OC(=O)C)OC(=O)C)(=O)C.[Na+].[O:15]1[C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=2[C:17]([CH2:24][CH:25]=O)=[CH:16]1.[NH:27]1[CH2:32][CH2:31][CH:30]([NH:33][C:34](=[O:40])[O:35][C:36]([CH3:39])([CH3:38])[CH3:37])[CH2:29][CH2:28]1.[OH-].[Na+]>ClCCl.C(O)(=O)C>[O:15]1[C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=2[C:17]([CH2:24][CH2:25][N:27]2[CH2:28][CH2:29][CH:30]([NH:33][C:34](=[O:40])[O:35][C:36]([CH3:38])([CH3:37])[CH3:39])[CH2:31][CH2:32]2)=[CH:16]1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

7

반응물 4

HCID 14798Sodium HydroxideHCID 7238334-(N-Boc-amino)piperidineHCID 5049666Sodium triacetoxyborohydrideHCID 18351319Benzo(b)furan-3-ylacetaldehyde

생성물 1

HCID 69491289HCID 69491289, 화합물

시약·촉매·용매 2

HCID 176Acetic Acid용매
HCID 6344
Dichloromethane
용매

실험 절차

13 ml of acetic acid and 61 g of sodium triacetoxyborohydride are added in succession to a solution of 33 g of 2-(benzofuran-3-yl)acetaldehyde and 41.3 g of tert-butyl 4-piperidylcarbamate in 1.4 litres of dichloromethane. After 24 hours' stirring at room temperature, a 20% sodium hydroxide solution is added. After 10 minutes, the reaction mixture is decanted and the organic phase is washed, dried and concentrated. Chromatography over silica gel (cyclohexane/ethyl acetate 30/70) enables the expected product to be isolated.

후처리

  1. waitAfter 10 minutes
  2. customthe reaction mixture is decanted
  3. washthe organic phase is washed
  4. customdried
  5. concentrationconcentrated
  6. customto be isolated

출처 및 근거

ORD 기록
ord-86f882e08c344f9aa0aabcef822b26d7
출처 데이터셋
uspto-grants-2001_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06323217B2

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