Hydrazine hydrate (1:1) → 3-phenyl-1H-indole-2-carbohydrazide
반응식
[C:1]1([C:7]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[NH:9][C:8]=2[C:16]([O:18]CC)=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.O.[NH2:22][NH2:23]>C(O)C>[C:1]1([C:7]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[NH:9][C:8]=2[C:16]([NH:22][NH2:23])=[O:18])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1참가 물질
4
실험 절차
A solution of Example 1B (2.65 g, 10 mmol) in ethanol (20 mL) was treated with hydrazine hydrate (3.12 mL, 100 mmol), heated to reflux for 18 hours, cooled to room temperature, and filtered. The resulting solid was washed with ethanol and dried under vacuum to provide 1.86 g (74%) of the desired product of sufficient purity for subsequent use.
후처리
- temperatureheated
- temperatureto reflux for 18 hours
- filtrationfiltered
- washThe resulting solid was washed with ethanol
- customdried under vacuum
출처 및 근거
- ORD 기록
- ord-8fb8d2c02ae042de967bb2addb26a35b
- 출처 데이터셋
- uspto-grants-2001_11
- 특허 번호
- US06323228B1
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