Methanol → N-Benzylacetamide

HRID 430703

반응식

HRID 430703 반응식
[CH2:1]([NH2:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(N(CC)CC)C.[C:16](Cl)(=[O:18])[CH3:17].CO>C(Cl)Cl>[C:16]([NH:8][CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)(=[O:18])[CH3:17]

참가 물질

6

반응물 4

HCID 887MethanolHCID 6367Acetyl chlorideHCID 7504BenzylamineHCID 8471Triethylamine

생성물 1

HCID 11500N-Benzylacetamide수율 61%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

10 g of benzylamine was dissolved in 200 ml of methylene chloride followed by the addition of 26 ml of triethylamine and dropwise addition of 7.3 ml of acetyl chloride at 0° C. After stirring for 1 hour at room temperature, 2 ml of methanol was added to the reaction system at 0° C. followed by 120 ml of water and separation of the phases. The aqueous layer was extracted with 100 ml of chloroform, and the resulting organic layer was concentrated after drying with anhydrous sodium sulfate to obtain 8.55 g of the target compound (yield: 61%).

후처리

  1. customfollowed by 120 ml of water and separation of the phases
  2. extractionThe aqueous layer was extracted with 100 ml of chloroform
  3. concentrationthe resulting organic layer was concentrated
  4. dry with materialafter drying with anhydrous sodium sulfate

출처 및 근거

ORD 기록
ord-9f8371a37d84470292733eecc32aa446
출처 데이터셋
uspto-grants-2001_11
특허 번호
US06323212B1

연결된 노트

불러오는 중…